Background: Multiple neurocognitive manifestations of COVID-19 have been reported. Symptomatic patients with COVID-19 typically present with respiratory symptoms but neurocognitive symptoms are common, especially in geriatric hospitalized patients with severe infection. Objective: To determine the prevalence and clinical impact of neurocognitive symptoms on the outcome of COVID-19 in geriatric patients. Patients and methods: A retrospective observational study conducted in Ain-Shams University Geriatrics hospital for isolation of COVID-19 patients. Number of included patients was 233 patients with positive Reverse Transcription Polymerase Chain Reaction (RT-PCR) results for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) infection. Length of stay was determined and mortality was the primary clinical outcome. Statistical analyses were performed. Results: We found that 54% of the studied cases had neurocognitive manifestations. Delirium and decline in consciousness levels were higher in deceased patients with statistically significant differences. There was a significant difference between alive and deceased groups regarding the presence of either neurocognitive or respiratory symptoms. A higher Acute Physiology and Chronic Health Evaluation II (APACHE II) score was significantly associated with a higher mortality rate. There were significant differences regarding TLC, serum sodium, Blood Urea Nitrogen (BUN), creatinine, albumin, C - C-reactive protein (CRP), Ferritin, and D-Dimer. Upon regression analysis, a higher APACHE II score was an independent risk factor for mortality. Conclusion: Neurocognitive manifestations were common among hospitalized geriatric patients with COVID-19 and were associated with poor hospital outcomes. Accordingly, these manifestations should be taken seriously and should receive early interventions to prevent undesirable events.
Mohamed Lotfy, M., Elsayed Elsorady, K., Ahmed Abdul-Rahman, S., & Shawky khater, M. (2023). Prevalence and clinical impact of neurocognitive symptoms in geriatric patients with COVID-19.. The Egyptian Journal of Geriatrics and Gerontology, 10(2), 51-64. doi: 10.21608/ejgg.2023.325913
MLA
Mahmoud Mohamed Lotfy; Khalid Elsayed Elsorady; Samia Ahmed Abdul-Rahman; Mohamed Shawky khater. "Prevalence and clinical impact of neurocognitive symptoms in geriatric patients with COVID-19.", The Egyptian Journal of Geriatrics and Gerontology, 10, 2, 2023, 51-64. doi: 10.21608/ejgg.2023.325913
HARVARD
Mohamed Lotfy, M., Elsayed Elsorady, K., Ahmed Abdul-Rahman, S., Shawky khater, M. (2023). 'Prevalence and clinical impact of neurocognitive symptoms in geriatric patients with COVID-19.', The Egyptian Journal of Geriatrics and Gerontology, 10(2), pp. 51-64. doi: 10.21608/ejgg.2023.325913
VANCOUVER
Mohamed Lotfy, M., Elsayed Elsorady, K., Ahmed Abdul-Rahman, S., Shawky khater, M. Prevalence and clinical impact of neurocognitive symptoms in geriatric patients with COVID-19.. The Egyptian Journal of Geriatrics and Gerontology, 2023; 10(2): 51-64. doi: 10.21608/ejgg.2023.325913
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