Relation between Hemodialysis and Oxidative Stress Markers’ blood levels in End Stage Renal Disease on Regular Dialysis

Hossam Arafat, Menna; Shawky Khater, Mohamed; Wahid Elsaid, Tamer; Ahmad Alsadany, Mohamad; Safwat Elaraby, Mennatallah

doi:10.21608/ejgg.2023.325920

Relation between Hemodialysis and Oxidative Stress Markers’ blood levels in End Stage Renal Disease on Regular Dialysis

Document Type : Original Article

Authors

¹ Geriatrics Medicine Department , Faculty of Medicine, Ain Shams University

² Internal Medicine and Nephrology Department , Faculty of Medicine, Ain Shams University

³ Geriatrics Medicine Department, Faculty of Medicine, Ain Shams University

10.21608/ejgg.2023.325920

Abstract

Background: Chronic kidney disease (CKD) is a common medical problem in the elderly. The progressive worsening of renal function in CKD induces numerous biological and clinical dysfunctions including augmentation of synthesis of inflammation and oxidative stress mediators.
Aim of the Work: The aim was to study the relation between the frequency of hemodialysis and oxidative stress markers’ blood levels in end-stage renal disease (ESRD) patients on regular dialysis.
Patients and Methods: This is a cross-sectional study that was done on a convenience sample of 80 cases of elderly patients, 60 years and older, who had ESRD and were on regular dialysis. The study was conducted in the hemodialysis unit at Ain Shams University Hospital (El-Demerdash). The study period was from the first of May 2021 to the end of November 2021.
Results: We found a statistically significant positive correlation between hemodialysis-related factors, namely duration of hemodialysis, number of sessions, duration of each session and the blood levels of oxidative stress markers.
Conclusion: Patients with ESRD on regular hemodialysis are at increased risk of oxidative stress risks as they are shown to have higher oxidative stress biological markers which are directly related to the duration of being on hemodialysis, the number of hemodialysis sessions and the duration of each session.

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