Patterns of biopsy-proved glomerular injury in Egyptian geriatric patients.

Document Type : Original Article

Authors

1 Department of Internal Medicine and Nephrology, Ain Shams University, Cairo, Egypt

2 Department of Geriatrics, Ain Shams University, Cairo, Egypt

3 Department of Pathology, Ain Shams University, Cairo, Egypt

4 Department of Internal Medicine, Modern University for Technology and Information

5 Department of Internal Medicine and Rheumatology, Ain Shams University, Cairo, Egypt

Abstract

Background: Chronic kidney disease (CKD) is considered a large burden in the elderly population. Many risk factors have been identified, however the pattern of involvement in this population remains unclear. Objectives: To detect the pattern of glomerular injury in the Egyptian geriatric population. Methods: We performed a single-centre, retrospective descriptive study on biopsy-proven renal diseases at Ain Shams University Pathology Unit; we included all biopsies with proven glomerular disease in geriatric patients aged ≥ 60 years (from 2018 to April 2023) to detect the pattern of glomerular injury in these patients throughout the last five years Results: Ninety-six renal biopsies with proved glomerular injury were included. In our study the mean age was 66.938±5.068, also 27.08% of our population were diabetic while 56.25% were hypertensive. Mean values for serum creatinine and protein/creatinine ratio on presentation are 4.240±2.20 and 4.257±1.97 respectively. In our study the majority of biopsies showed Focal segmental Glomerulosclerosis (30.21%), it was followed by Membranous Glomerulonephritis (12.5%), Diabetic Glomerulosclerosis, Diffuse Proliferative Glomerulonephritis and Diffuse Glomerulosclerosis came next (11.46,11.46 and 10.42 % respectively) Conclusion: Focal segmental glomerulosclerosis seemed to be the most prevalent type of glomerulonephritis in elderly Egyptian patients although these results need to verify on a larger scale of patients.

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