Association of C-Reactive Protein, Tumor Necrosis Factor-Alpha, and Interleukin-With Chronic Kidney Disease in Elderly.

Mahmoud Ali Ramadan, Ali; Hassan Mohamed, Azza; Ahmed Saad, Marwa; Moustafa Tahoun, Mona; Emad Eldeen Mohy Eldeen Hamoda, Mohamed; Hussein Arafa, Mohamed

doi:10.21608/ejgg.2024.382689

Association of C-Reactive Protein, Tumor Necrosis Factor-Alpha, and Interleukin-With Chronic Kidney Disease in Elderly.

Document Type : Original Article

Authors

¹ Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.

² Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt

10.21608/ejgg.2024.382689

Abstract

Background: Chronic kidney disease (CKD) is a significant decrease in kidney function that is long-lasting, irreversible, and typically progressive. It has been demonstrated that there is a correlation between the rates of morbidity and mortality of CKD and systemic inflammation.
Objective: This study's objective was to assess the correlation between C-reactive protein, interleukin-6, and tumour necrosis factor-alpha and chronic kidney disease in elderly patients.
Material and methods: Eighty participants 65 years old or older were included in the study, and they were split into 40 CKD patients(cases) and 40 subjects(controls). Every patient had a detailed medical history gathered, a clinical assessment, and abdominal and pelvic ultrasound to evaluate their kidney function. Laboratory investigations included serum of interleukin-6(IL-6), tumor necrosis factor-alpha(TNFα), highly sensitivity C-reactive protein (hs-CRP), electrolytes (Na, K, Ca, P), virology (HCV ab, HBVs Ag, HIV), CBC, postprandial blood glucose (PPS), fasting blood glucose (FBS), creatinine, urea, albumin /creatinine ratio in urine and lipid profile.
Results: In the CKD group, the mean value of IL-6 levels was 181.58 ± 130.63.among the control group the mean was 88.07 ± 86.90. The mean value of CRP among the cases group was 42.02 ± 24.85 and among the control group was 14.95 ± 11.70. The mean value of TNF alpha among the cases group was 358.34 ± 255.48 and among the control group was 188.99 ± 196.76.
Conclusion: The blood levels of tumour necrosis factor-alpha, interleukin 6, and C reactive protein varied statistically significantly in CKD patients and controls.

Keywords