The aim of the study is to assess the effectiveness of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection in Egyptian elderly patients with normal liver and kidney functions. Methods: The study was experimental study carried out on 34 elderly patients having H. pylori gastritis with normal liver and kidney functions. We tested for H. pylori stool antigen using a quantitative monoclonal enzyme-linked immunosorbent assay (ELISA) assay before and 4 weeks after the treatment to confirm eradication. Patients received Clarithromycin-based triple therapy (Clarithromycin 500mg twice daily, Amoxicillin 1000mg twice daily, and Omeprazole 40mg twice daily) for H. pylori eradication for 14 days. Results: The cure rate of Clarithromycinbased triple therapy was 88.2% (30/34) and only 11.8% (4/34) was having persistent infection. None of the patients discontinued the drugs indicating good tolerability .Conclusion: The use of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection is highly effective and tolerable in Egyptian elderly patients with normal liver and kidney functions.
M, S., M., G., A., D., & H, E. (2015). Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients. The Egyptian Journal of Geriatrics and Gerontology, 2(1), 19-26. doi: 10.21608/ejgg.2015.5342
MLA
Salamah M; Gad M.; Deghady A.; Elgayar H. "Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients", The Egyptian Journal of Geriatrics and Gerontology, 2, 1, 2015, 19-26. doi: 10.21608/ejgg.2015.5342
HARVARD
M, S., M., G., A., D., H, E. (2015). 'Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients', The Egyptian Journal of Geriatrics and Gerontology, 2(1), pp. 19-26. doi: 10.21608/ejgg.2015.5342
VANCOUVER
M, S., M., G., A., D., H, E. Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients. The Egyptian Journal of Geriatrics and Gerontology, 2015; 2(1): 19-26. doi: 10.21608/ejgg.2015.5342
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